3,6'-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury.

Huang, Pen-Sen; Tsai, Ping-Yen; Yang, Ling-Yu; Lecca, Daniela; Luo, Weiming; Kim, Dong Seok; Hoffer, Barry J; Chiang, Yung-Hsiao; Greig, Nigel H; Wang, Jia-Yi

Huang, Pen-Sen; Tsai, Ping-Yen; Yang, Ling-Yu; Lecca, Daniela; Luo, Weiming; Kim, Dong Seok; Hoffer, Barry J; Chiang, Yung-Hsiao; Greig, Nigel H; Wang, Jia-Yi.

Afiliação

Huang PS; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Tsai PY; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yang LY; School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Lecca D; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Luo W; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Kim DS; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Hoffer BJ; Aevis Bio, Inc., Daejeon 34141, Korea.
Chiang YH; Aevis Bio, Inc., Gaithersburg, MD 20878, USA.
Greig NH; Department of Neurological Surgery, Case Western Reserve University, Cleveland, OH 44106, USA.
Wang JY; Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan.

Int J Mol Sci ; 22(15)2021 Jul 31.

Article em En | MEDLINE | ID: mdl-34361041

Assuntos

Lesões Encefálicas Traumáticas/tratamento farmacológico; Gliose/tratamento farmacológico; Hipocampo/efeitos dos fármacos; Fatores Imunológicos/uso terapêutico; Fármacos Neuroprotetores/uso terapêutico; Talidomida/análogos & derivados; Animais; Lesões Encefálicas Traumáticas/complicações; Cognição; Gliose/etiologia; Hipocampo/metabolismo; Fatores Imunológicos/farmacologia; Masculino; Memória; Fármacos Neuroprotetores/farmacologia; Ratos; Ratos Sprague-Dawley; Talidomida/farmacologia; Talidomida/uso terapêutico

Palavras-chave

3,6'-dithiopomalidomide; astrogliosis; cognitive deficits; immunomodulatory imide drugs; microgliosis; neurodegeneration; neuroinflammation; pomalidomide; traumatic brain injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Talidomida / Fármacos Neuroprotetores / Lesões Encefálicas Traumáticas / Gliose / Hipocampo / Fatores Imunológicos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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