Bioactive Compounds from Lemon (Citrus limon) Extract Overcome TNF-α-Induced Insulin Resistance in Cultured Adipocytes.
Molecules
; 26(15)2021 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-34361563
ABSTRACT
The consumption of plant-based food is important for health promotion, especially regarding the prevention and management of chronic diseases such as diabetes. We investigated the effects of a lemon extract (LE), containing ≥20.0% total flavanones and ≥1.0% total hydroxycinnamic acids, on insulin signaling in murine 3T3-L1 adipocytes treated with TNF-α, which was used to mimic in vitro the insulin resistance condition that characterizes diabetes mellitus. Our results showed LE increased PPARγ, GLUT4 and DGAT-1 levels, demonstrating the potential of this lemon extract in the management of insulin resistance conditions associated with TNF-α pathway activation. LE treatment further decreased the release of interleukin 6 (IL-6) and restored triglyceride synthesis, which is the main feature of a healthy adipocyte.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
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Extratos Vegetais
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Fator de Necrose Tumoral alfa
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Citrus
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Adipócitos
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Compostos Fitoquímicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article