Neuroprotective and Anti-Inflammatory Effects of <i>Pinus densiflora</i> Bark Extract in Gerbil Hippocampus Following Transient Forebrain Ischemia.

Park, Joon Ha; Kim, Jong Dai; Lee, Tae-Kyeong; Han, Xionggao; Sim, Hyejin; Kim, Bora; Lee, Jae-Chul; Ahn, Ji Hyeon; Lee, Choong-Hyun; Kim, Dae Won; Won, Moo-Ho; Choi, Soo Young

Neuroprotective and Anti-Inflammatory Effects of Pinus densiflora Bark Extract in Gerbil Hippocampus Following Transient Forebrain Ischemia.

Park, Joon Ha; Kim, Jong Dai; Lee, Tae-Kyeong; Han, Xionggao; Sim, Hyejin; Kim, Bora; Lee, Jae-Chul; Ahn, Ji Hyeon; Lee, Choong-Hyun; Kim, Dae Won; Won, Moo-Ho; Choi, Soo Young.

Afiliação

Park JH; Department of Anatomy, College of Korean Medicine, Dongguk University, Gyeongju 38066, Korea.
Kim JD; Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Korea.
Lee TK; Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Han X; Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Korea.
Sim H; Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Kim B; Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Lee JC; Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Ahn JH; Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Lee CH; Department of Physical Therapy, College of Health Science, Youngsan University, Yangsan 50510, Korea.
Kim DW; Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Korea.
Won MH; Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangnung-Wonju National University, Gangneung 25457, Korea.
Choi SY; Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.

Molecules ; 26(15)2021 Jul 29.

Article em En | MEDLINE | ID: mdl-34361744

Assuntos

Anti-Inflamatórios/farmacologia; Isquemia Encefálica/tratamento farmacológico; Hipocampo/efeitos dos fármacos; Fármacos Neuroprotetores/farmacologia; Pinus/química; Prosencéfalo/efeitos dos fármacos; Animais; Anti-Inflamatórios/química; Isquemia Encefálica/genética; Isquemia Encefálica/metabolismo; Isquemia Encefálica/patologia; Flavonoides/química; Flavonoides/farmacologia; Expressão Gênica/efeitos dos fármacos; Gerbillinae; Hipocampo/metabolismo; Hipocampo/patologia; Inflamação; Interleucina-13/agonistas; Interleucina-13/genética; Interleucina-13/metabolismo; Interleucina-1beta/antagonistas & inibidores; Interleucina-1beta/genética; Interleucina-1beta/metabolismo; Interleucina-4/agonistas; Interleucina-4/genética; Interleucina-4/metabolismo; Masculino; Microglia/efeitos dos fármacos; Microglia/metabolismo; Microglia/patologia; Fármacos Neuroprotetores/química; Casca de Planta/química; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Polifenóis/química; Polifenóis/farmacologia; Proantocianidinas/química; Proantocianidinas/farmacologia; Prosencéfalo/metabolismo; Prosencéfalo/patologia; Células Piramidais/efeitos dos fármacos; Células Piramidais/metabolismo; Células Piramidais/patologia; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

flavonoids; hippocampus; inflammatory cytokines; microgliosis; polyphenols; proanthocyanidins; pyramidal neuron

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Prosencéfalo / Fármacos Neuroprotetores / Pinus / Hipocampo / Anti-Inflamatórios Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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