LncRNA CDKN2BAS1 sponges miR285p to regulate proliferation and inhibit apoptosis in colorectal cancer.
Oncol Rep
; 46(4)2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34368874
ABSTRACT
Long noncoding RNA (lncRNA) CDKN2Bantisense RNA 1 (AS1) functions as a tumor oncogene in numerous cancers. However, the roles and mechanism of CDKN2BAS1 in colorectal cancer (CRC) have not been explored. The present study aimed to investigate whether and how CDKN2BAS1 contributes to CRC progression. The data revealed that CDKN2BAS1 expression was upregulated in CRC tissues. Lossoffunction assays demonstrated that CDKN2BAS1 in CRC modulated cell proliferation and apoptosis, which was mediated by cyclin D1, cyclindependent kinase (CDK) 4, pRb, caspase9 and caspase3. Bioinformatics analysis and luciferase reporter assays indicated direct binding of microRNA (miR)285p to CDKN2BAS1. Moreover, the results herein revealed that the expression of miR285p was negatively correlated with that of CDKN2BAS1 in CRC tissue. Moreover, CDKN2BAS1 acted as a miR285p competing endogenous RNA (ceRNA) to target and regulate the expression of URGCP. These findings indicated that CDKN2BAS1 plays roles in CRC progression, providing a potential therapeutic target or novel diagnostic biomarker for CRC.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Apoptose
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MicroRNAs
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Proliferação de Células
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RNA Longo não Codificante
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article