Gastrointestinal Tolerance and Protein Absorption Markers with a New Peptide Enteral Formula Compared to a Standard Intact Protein Enteral Formula in Critically Ill Patients.
Nutrients
; 13(7)2021 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-34371872
ABSTRACT
The aim of this exploratory study was to investigate gastrointestinal tolerance and protein absorption markers with a new enteral peptide formula (PF) compared to an isocaloric enteral intact protein standard formula (SF) containing the same amount of protein in ICU patients. Patients admitted to a cardio-thoracic intensive care unit expected to receive tube feeding for ≥5 days were randomized to receive either PF (1.5 kcal/mL) or SF in a double-blind manner for ≤14 days. Twenty-six patients were randomized (13 SF and 13 PF) and 23 (12 SF and 11 PF) completed at least 5 days of product administration. There were no statistically significant differences between the feeds during the first 5 days of intervention for diarrhea (SF3 (23%); PF5 (39%), p = 0.388), vomiting (SF1 (8%); PF2 (15%), p = 0.549), constipation (SF7 (54%), PF3 (23%), p = 0.115), and high gastric residual volume (>500 mL SF1 (8%); PF 2 (15%), p = 0.535). There were no differences in plasma amino acids or urinary markers of protein absorption and metabolism. In conclusion, no major differences were found in tolerability and protein absorption markers between the standard intact protein formula and the peptide formula.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hidrolisados de Proteína
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Proteínas Alimentares
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Alimentos Formulados
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Estado Terminal
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Nutrição Enteral
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Absorção Intestinal
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Valor Nutritivo
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article