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Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany - a case report.
Tappe, Dennis; Pörtner, Kirsten; Frank, Christina; Wilking, Hendrik; Ebinger, Arnt; Herden, Christiane; Schulze, Christoph; Muntau, Birgit; Eggert, Petra; Allartz, Petra; Schuldt, Gerlind; Schmidt-Chanasit, Jonas; Beer, Martin; Rubbenstroth, Dennis.
Afiliação
  • Tappe D; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany. tappe@bnitm.de.
  • Pörtner K; Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
  • Frank C; Postgraduate Training for Applied Epidemiology (PAE) affiliated with the European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
  • Wilking H; Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
  • Ebinger A; Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
  • Herden C; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Riems, Germany.
  • Schulze C; Institute for Veterinary Pathology, Justus-Liebig-University Gießen, Gießen, Germany.
  • Muntau B; Landeslabor Berlin-Brandenburg, Frankfurt (Oder), Germany.
  • Eggert P; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
  • Allartz P; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
  • Schuldt G; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
  • Schmidt-Chanasit J; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
  • Beer M; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
  • Rubbenstroth D; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Riems, Germany.
BMC Infect Dis ; 21(1): 787, 2021 Aug 10.
Article em En | MEDLINE | ID: mdl-34376142
ABSTRACT

BACKGROUND:

The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. CASE PRESENTATION A retrospective laboratory and epidemiological investigation of a 2017 case of fatal encephalitis in a farmer in Brandenburg, northeast Germany, demonstrated BoDV-1 as causative agent by polymerase chain reaction, immunohistochemistry and in situ hybridization. Next-generation sequencing showed that the virus belonged to a cluster not known to be endemic in Brandenburg. The investigation was triggered by a recent outbreak of animal Borna disease in the region. Multiple possible exposures were identified. The next-of-kin were seronegative.

CONCLUSIONS:

The investigation highlights clinical awareness for human BoDV-1 encephalitis which should be extended to all areas endemic for animal Borna disease. All previously diagnosed human cases had occurred > 350 km further south. Further testing of shrews and livestock with Borna disease may show whether this BoDV-1 cluster is additionally endemic in the northwest of Brandenburg.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Borna / Vírus da Doença de Borna / Encefalite Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País como assunto: Europa Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Borna / Vírus da Doença de Borna / Encefalite Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País como assunto: Europa Idioma: En Ano de publicação: 2021 Tipo de documento: Article