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Ten Years of EWAS.
Wei, Siyu; Tao, Junxian; Xu, Jing; Chen, Xingyu; Wang, Zhaoyang; Zhang, Nan; Zuo, Lijiao; Jia, Zhe; Chen, Haiyan; Sun, Hongmei; Yan, Yubo; Zhang, Mingming; Lv, Hongchao; Kong, Fanwu; Duan, Lian; Ma, Ye; Liao, Mingzhi; Xu, Liangde; Feng, Rennan; Liu, Guiyou; Project, The Ewas; Jiang, Yongshuai.
Afiliação
  • Wei S; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Tao J; The EWAS Project, Harbin, China.
  • Xu J; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Chen X; The EWAS Project, Harbin, China.
  • Wang Z; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Zhang N; The EWAS Project, Harbin, China.
  • Zuo L; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Jia Z; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Chen H; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Sun H; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Yan Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Zhang M; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Lv H; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Kong F; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Duan L; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Ma Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Liao M; The EWAS Project, Harbin, China.
  • Xu L; Department of Nephrology, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
  • Feng R; The EWAS Project, Harbin, China.
  • Liu G; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Project TE; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Jiang Y; The EWAS Project, Harbin, China.
Adv Sci (Weinh) ; 8(20): e2100727, 2021 10.
Article em En | MEDLINE | ID: mdl-34382344
ABSTRACT
Epigenome-wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next-generation, and third-generation sequencing technologies have prepared a high-quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Predisposição Genética para Doença / Epigenoma / Doenças Genéticas Inatas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Predisposição Genética para Doença / Epigenoma / Doenças Genéticas Inatas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article