Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal.

Wang, Zhenqing; Chen, Liang; Ma, Yiqun; Li, Xilei; Hu, Annan; Wang, Huiren; Wang, Wenxing; Li, Xiaomin; Tian, Bo; Dong, Jian

Wang, Zhenqing; Chen, Liang; Ma, Yiqun; Li, Xilei; Hu, Annan; Wang, Huiren; Wang, Wenxing; Li, Xiaomin; Tian, Bo; Dong, Jian.

Afiliação

Wang Z; Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Chen L; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Ma Y; Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, People's Republic of China.
Li X; Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Hu A; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Wang H; Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Wang W; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Li X; Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Tian B; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Dong J; Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

J Nanobiotechnology ; 19(1): 243, 2021 Aug 12.

Article em En | MEDLINE | ID: mdl-34384429

Assuntos

Inibidores de Checkpoint Imunológico/farmacologia; Morte Celular Imunogênica/efeitos dos fármacos; Imunoterapia/métodos; Metástase Neoplásica/tratamento farmacológico; Vacinas de Subunidades Antigênicas/farmacologia; Animais; Antígeno B7-H1/efeitos dos fármacos; Antígeno B7-H1/metabolismo; Linfócitos T CD8-Positivos; Linhagem Celular Tumoral; Citocinas; Feminino; Inibidores de Checkpoint Imunológico/química; Camundongos; Camundongos Endogâmicos C57BL; Nanopartículas/química; Nanopartículas/uso terapêutico; Fotoquimioterapia; Fármacos Fotossensibilizantes/farmacologia; Receptor de Morte Celular Programada 1/metabolismo; Coluna Vertebral; Vacinas de Subunidades Antigênicas/química

Palavras-chave

Immunogenic cell death; Peptide vaccine; Photodynamic therapy; Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) blockades; Spine metastasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas de Subunidades Antigênicas / Morte Celular Imunogênica / Inibidores de Checkpoint Imunológico / Imunoterapia / Metástase Neoplásica Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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