Cephalotaxine-type alkaloids from the seeds of Cephalotaxus fortunei and their cytotoxic activities.
Phytochemistry
; 191: 112903, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-34384922
ABSTRACT
Six new Cephalotaxus alkaloids, including five cephalotaxine-type alkaloids, and one homoerythrina-type alkaloid, along with six known analogues, were isolated from the seeds of Cephalotaxus fortunei. Their structures were elucidated by combination of spectroscopic data analyses, time-dependent density functional theory (TDDFT) ECD calculation, and single-crystal X-ray diffraction. Cephalofortine B represents the first example of C-5 epi-cephalotaxine-type alkaloid. All isolated compounds were tested for cytotoxicities against HCT-116, A375, and SK-Mel-28 cell lines. Cephalofortine E showed moderate activity against HCT-116 cell line, with an IC50 value of 7.46 ± 0.77 µM.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cephalotaxus
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Alcaloides
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Harringtoninas
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article