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The use of negative oxygen ion clusters [O2-(H2O)n] and bicarbonate ions [HCO3-] as the supportive treatment of COVID-19 infections: A possibility.
Badhe, Ravindra V; Nipate, Sonali S.
Afiliação
  • Badhe RV; SidIra Laboratories, Moshi, Pune, Maharashtra, India. Electronic address: badheravi2@gmail.com.
  • Nipate SS; SidIra Laboratories, Moshi, Pune, Maharashtra, India; Pharmacology Department, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.
Med Hypotheses ; 154: 110658, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34390895
ABSTRACT
The COVID-19 or novel coronavirus SARS-CoV-2 pandemic is challenging worldwide healthcare system and severely affecting global economy. Furious efforts to end the pandemic including prevention of spread of SARS-CoV-2, use of antiviral drugs, symptomatic treatments and vaccination are underway. But there are no effective treatments available to save the dying patient in stage 2 (pulmonary) and stage 3 (hyperinflammation) of the infection. The detailed genetic and phenotypical analysis of SARS-CoV-2 revealed that the spike protein (S1) has increased positive charges (compared to SARS-CoV) on them and are responsible for attachment to human angiotensin-converting enzyme 2 (ACE2) receptor and infection by the virus. In addition, it was also reported that the inflammation in the tissue rendered the lung environment more acidic supporting the fusion of SARS-CoV-2 with the cells. We hypothesize that the intermittent use of the oxygen ionizer generating negative oxygen ion clusters [O2-(H2O)n] and sodium bicarbonate nebulizer (generating HCO3-); when connected to ventilator inlet or oxygen concentrator will neutralize the spike protein of the virus in respiratory tract and lungs and change the lung environment to neutral/alkaline condition respectively facilitating improved oxygen pressure in blood. These physical changes can effectively reduce the viral burden and help the patient recover from the infection faster.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bicarbonatos / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bicarbonatos / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article