Memory B cells and plasma cells: The differentiative continuum of humoral immunity.
Immunol Rev
; 303(1): 72-82, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34396546
ABSTRACT
Immunological memory is a composite of lasting antibody titers maintained by plasma cells in conjunction with memory T and B cells. Memory B cells are a critical reservoir for plasma cell generation in the secondary response. Identification of memory B cells requires that they be distinguished from naïve, activated, and germinal center precursors and from plasma cells. Memory B cells are heterogeneous in isotype usage, immunoglobulin mutational content, and phenotypic marker expression. Phenotypic subsets of memory B cells are defined by PD-L2, CD80, and CD73 expression in mice, by CD27 and FCRL4 expression in humans and by T-bet in both mice and humans. These subsets display marked functional heterogeneity, including the ability to rapidly differentiate into plasma cells versus seed germinal centers in the secondary response. Memory B cells are located in the spleen, blood, other lymphoid organs, and barrier tissues, and recent evidence indicates that some memory B cells may be dedicated tissue-resident populations. Open questions about memory B cell longevity, renewal and progenitor-successor relationships with plasma cells are discussed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Imunidade Humoral
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article