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Participants on Dolutegravir Resuppress Human Immunodeficiency Virus RNA After Virologic Failure: Updated Data from the ADVANCE Trial.
Pepperrell, Toby; Venter, Willem Daniel Francois; McCann, Kaitlyn; Bosch, Bronwyn; Tibbatts, Melissa; Woods, Joanna; Sokhela, Simiso; Serenata, Celicia; Moorhouse, Michelle; Qavi, Ambar; Hill, Andrew.
Afiliação
  • Pepperrell T; Faculty of Medicine, Imperial College London, London, United Kingdom.
  • Venter WDF; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • McCann K; School of Public Health, Imperial College London, London, United Kingdom.
  • Bosch B; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Tibbatts M; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Woods J; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Sokhela S; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Serenata C; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Moorhouse M; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Qavi A; School of Public Health, Imperial College London, London, United Kingdom.
  • Hill A; Department of Translational Medicine, Liverpool University, Pharmacology, Liverpool, United Kingdom.
Clin Infect Dis ; 73(4): e1008-e1010, 2021 08 16.
Article em En | MEDLINE | ID: mdl-34398955
ABSTRACT
Following evidence of HIV RNA re-suppression on DTG-based regimens, we assess the re-suppressive capacity of ADVANCE participants on TAF/FTC+DTG, TDF/FTC+DTG, and TDF/FTC/EFV. Viraemic participants were able to re-suppress within 3 follow-up visits of protocol-defined virological failure (PDVF) in 77/121 (64%), 85/126 (67%), and 44/138 (32%) cases respectively (DTG regimens vs. TDF/FTC/EFV; P < 0.001).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article