Efficient conversion of phytosterols into 4-androstene-3,17-dione and its C1,2-dehydrogenized and 9&#945;-hydroxylated derivatives by engineered Mycobacteria.

Li, Xin; Chen, Tian; Peng, Fei; Song, Shikui; Yu, Jingpeng; Sidoine, Douanla Njimeli; Cheng, Xiyao; Huang, Yongqi; He, Yijun; Su, Zhengding

Efficient conversion of phytosterols into 4-androstene-3,17-dione and its C1,2-dehydrogenized and 9α-hydroxylated derivatives by engineered Mycobacteria.

Li, Xin; Chen, Tian; Peng, Fei; Song, Shikui; Yu, Jingpeng; Sidoine, Douanla Njimeli; Cheng, Xiyao; Huang, Yongqi; He, Yijun; Su, Zhengding.

Afiliação

Li X; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Chen T; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Peng F; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Song S; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Yu J; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Sidoine DN; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Cheng X; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
Huang Y; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.
He Y; Hubei Goto Biotech Inc., No. 1 Baiguoshu Road, Shuidu Industrial Park, Danjiangkou, 442700, Hubei, China. heyijun@gotochem.com.
Su Z; Key Laboratory of Industrial Fermentation (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics and Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China. zhengdingsu@hbut.edu.cn.

Microb Cell Fact ; 20(1): 158, 2021 Aug 16.

Article em En | MEDLINE | ID: mdl-34399754

Assuntos

Androstenodiona/análogos & derivados; Androstenodiona/metabolismo; Mycobacterium/genética; Mycobacterium/metabolismo; Fitosteróis/metabolismo; Hidroxilação; Oxigenases de Função Mista

Palavras-chave

1,4-Androstadiene-3,17-dione (ADD); 21-Hydroxy-20-methylpregn-4-en-3-one (BA); 3-Ketosteroid-1,2-dehydrogenase (KstD); 3-Ketosteroid-9α-hydroxylase (Ksh); 4-Androstene-3,17-dione (4-AD); 9α-Hydroxyl-4-androstene-3,17-dione (9OH-AD); Mycobacterium sp. strain

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fitosteróis / Androstenodiona / Mycobacterium Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fitosteróis / Androstenodiona / Mycobacterium Idioma: En Ano de publicação: 2021 Tipo de documento: Article