Fast and Efficient Genome Editing of Human FOXP3<sup>+</sup> Regulatory T Cells.

Van Zeebroeck, Lauren; Arroyo Hornero, Rebeca; Côrte-Real, Beatriz F; Hamad, Ibrahim; Meissner, Torsten B; Kleinewietfeld, Markus

Fast and Efficient Genome Editing of Human FOXP3⁺ Regulatory T Cells.

Van Zeebroeck, Lauren; Arroyo Hornero, Rebeca; Côrte-Real, Beatriz F; Hamad, Ibrahim; Meissner, Torsten B; Kleinewietfeld, Markus.

Afiliação

Van Zeebroeck L; Vlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Arroyo Hornero R; Department of Immunology, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Côrte-Real BF; Vlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Hamad I; Department of Immunology, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Meissner TB; Vlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Kleinewietfeld M; Department of Immunology, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

Front Immunol ; 12: 655122, 2021.

Article em En | MEDLINE | ID: mdl-34408743

Assuntos

Edição de Genes/métodos; Subunidade alfa de Receptor de Interleucina-2/genética; Receptores de Interleucina-6/genética; Linfócitos T Reguladores/metabolismo; Buffy Coat/citologia; Sistemas CRISPR-Cas/genética; Fatores de Transcrição Forkhead/metabolismo; Técnicas de Silenciamento de Genes; Células HEK293; Voluntários Saudáveis; Humanos; Imunoterapia Adotiva/métodos; Cultura Primária de Células; RNA Guia de Cinetoplastídeos/genética; Fatores de Tempo

Palavras-chave

CD4; COVID-19; CRISPR; IL6R; autoimmunity; genome editing; human; regulatory T cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Receptores de Interleucina-6 / Subunidade alfa de Receptor de Interleucina-2 / Edição de Genes Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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