A comparative study of immunotherapy as second-line treatment and beyond in patients with advanced non-small-cell lung carcinoma.
Lung Cancer Manag
; 10(3): LMT47, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-34408789
ABSTRACT
BACKGROUND:
Immunotherapy has demonstrated an improved overall survival (OS) and progression-free survival (PFS) as second-line treatment and subsequent lines compared with chemotherapy. MATERIALS &METHODS:
This was a retrospective review among eight medical centers comprising 100 patients with a confirmed diagnosis of non-small-cell lung carcinoma, in their second-line treatment or beyond with immune checkpoints inhibitors treatment. The current study aimed to analyze effectiveness of immunotherapy in second-line treatment or further in the Mexican population, using PFS rate, OS rate and the best objective response to treatment by RECIST 1.1 as a surrogate of effectiveness.RESULTS:
In total, 100 patients met the criteria for enrollment in the current study. From the total study population, 49 patients (49.0%) were male and 51 (51.0%) were female, with an average age of 60 years and stage IV as the most prevalent clinical stage at the beginning of the study. A total of 61 patients (61.0%) had partial response; 11 (11.0%) stable disease; 2 (2.0%), complete response, 4 (4.0%), progression; and 22 (22.0%) were nonevaluable. We found a median PFS of 4 months (95% CI 3.2-4.7 months) and an OS of 9 months (95% CI 7.2-10.7 months).CONCLUSION:
The response to immunotherapy is similar, with an improvement in OS and PFS, independent of which drug is used. Patients using nivolumab had a better survival, although that was not statistically significant.
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MEDLINE
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Ano de publicação:
2021
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Article