The association of BMI and sarcopenia with survival in patients with glioblastoma multiforme.
Future Oncol
; 17(32): 4405-4413, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-34409854
ABSTRACT
Background:
The association between obesity and sarcopenia (via temporal muscle thickness) with overall survival (OS) has been evaluated in several glioblastoma multiforme studies, however, the data are inconclusive.Methods:
The authors conducted meta-analyses via the generic inverse-variance method with a random-effects model.Results:
In the pooled analysis of five studies, including 973 patients, patients with lower temporal muscle thickness had significantly decreased OS (HR 1.62, 95% CI 1.16-2.28, p = 0.005). The pooled analysis of five studies, including 2131 patients, demonstrated decreased OS in patients with lower BMI compared with patients with obesity (HR 1.45, 95% CI 1.12-1.88, p = 0.005).Conclusion:
Readily available body composition parameters could be used for prognosis prediction and to aid in treatment decisions in patients with glioblastoma multiforme.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Glioblastoma
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Sarcopenia
/
Obesidade
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article