Partners with a killer: Metabolic signaling promotes inflammatory cell death.
Cell
; 184(17): 4374-4376, 2021 08 19.
Article
em En
| MEDLINE
| ID: mdl-34416144
ABSTRACT
In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.
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1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos e Proteínas de Sinalização Intracelular
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Piroptose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article