A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation.
J Immunol
; 207(6): 1652-1661, 2021 09 15.
Article
em En
| MEDLINE
| ID: mdl-34426543
ABSTRACT
The IκB kinase (IKK) complex plays a vital role in regulating the NF-κB activation. Aberrant NF-κB activation is involved in various inflammatory diseases. Thus, targeting IKK activation is an ideal therapeutic strategy to cure and prevent inflammatory diseases related to NF-κB activation. In a previous study, we demonstrated that IKK-interacting protein (IKIP) inhibits the phosphorylation of IKKα/ß and the activation of NF-κB through disruption of the formation of IKK complex. In this study, we identified a 15-aa peptide derived from mouse IKIP (46-60 aa of IKIP), which specifically suppressed IKK activation and NF-κB targeted gene expression via disrupting the association of IKKß and NEMO. Importantly, administration of the peptide reduced LPS-induced acute inflammation and attenuated Zymosan-induced acute arthritis in mice. These findings suggest that this IKIP peptide may be a promising therapeutic reagent in the prevention and treatment of inflammatory diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Transdução de Sinais
/
NF-kappa B
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Peptídeos e Proteínas de Sinalização Intracelular
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Quinase I-kappa B
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article