Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.
BMC Microbiol
; 21(1): 235, 2021 08 24.
Article
em En
| MEDLINE
| ID: mdl-34429063
ABSTRACT
BACKGROUND:
The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. While there have been major advances in the characterization of colibactin-positive E. coli and the toxin it produces, the infection route of the clb + strain remains poorly characterized.RESULTS:
We examined infants and their treatments during and post-birth periods to examine potential transmission of colibactin-positive E. coli to infants. Here, analysis of fecal samples of infants over the first month of birth for the presence of a colibactin biosynthetic gene revealed that the bacterium may be transmitted from mother to infant through intimate contacts, such as natural childbirth and breastfeeding, but not through food intake.CONCLUSIONS:
Our finding suggests that transmission of colibactin-positive E. coli appears to be occurring at the very early stage of life of the newborn and hints at the possibility of developing early preventive measures against colorectal cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Toxinas Bacterianas
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Carcinógenos
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Neoplasias Colorretais
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Transmissão Vertical de Doenças Infecciosas
/
Escherichia coli
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Infecções por Escherichia coli
/
Policetídeos
Tipo de estudo:
Etiology_studies
/
Screening_studies
Limite:
Female
/
Humans
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Male
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Newborn
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article