M1 macrophage-derived exosomes aggravate bone loss in postmenopausal osteoporosis via a microRNA-98/DUSP1/JNK axis.

Yu, Long; Hu, Ming; Cui, Xu; Bao, Da; Luo, Zhanpeng; Li, Dawei; Li, Litao; Liu, Ning; Wu, Yunfeng; Luo, Xiaobo; Ma, Yuanzheng

Yu, Long; Hu, Ming; Cui, Xu; Bao, Da; Luo, Zhanpeng; Li, Dawei; Li, Litao; Liu, Ning; Wu, Yunfeng; Luo, Xiaobo; Ma, Yuanzheng.

Afiliação

Yu L; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Hu M; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Cui X; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Bao D; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Luo Z; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Li D; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Li L; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Liu N; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Wu Y; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Luo X; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Ma Y; Department of Spine Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.

Cell Biol Int ; 45(12): 2452-2463, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34431160

Assuntos

Fosfatase 1 de Especificidade Dupla/metabolismo; Exossomos/metabolismo; Sistema de Sinalização das MAP Quinases/fisiologia; Macrófagos/metabolismo; MicroRNAs/metabolismo; Osteoporose Pós-Menopausa/metabolismo; Osteoporose/metabolismo; Células 3T3; Animais; Diferenciação Celular/fisiologia; Linhagem Celular; Modelos Animais de Doenças; Regulação para Baixo/fisiologia; Feminino; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Osteoblastos/metabolismo; Osteogênese/fisiologia; Células RAW 264.7; Regulação para Cima/fisiologia

Palavras-chave

DUSP1; JNK; M1 macrophages; exosomes; osteoporosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Osteoporose Pós-Menopausa / Sistema de Sinalização das MAP Quinases / MicroRNAs / Fosfatase 1 de Especificidade Dupla / Exossomos / Macrófagos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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