Infections at the maternal-fetal interface: an overview of pathogenesis and defence.
Nat Rev Microbiol
; 20(2): 67-82, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34433930
Infections are a major threat to human reproductive health, and infections in pregnancy can cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to congenital infection and severe disease. The acronym 'TORCH' (Toxoplasma gondii, other, rubella virus, cytomegalovirus, herpes simplex virus) refers to pathogens directly associated with the development of congenital disease and includes diverse bacteria, viruses and parasites. The placenta restricts vertical transmission during pregnancy and has evolved robust mechanisms of microbial defence. However, microorganisms that cause congenital disease have likely evolved diverse mechanisms to bypass these defences. In this Review, we discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transmissão Vertical de Doenças Infecciosas
/
Doenças Fetais
Tipo de estudo:
Etiology_studies
Limite:
Female
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Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article