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Shining light on location-biased cAMP signaling.
Vilardaga, Jean-Pierre; Sutkeviciute, Ieva; Peña, Karina A.
Afiliação
  • Vilardaga JP; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, USA. Electronic address: jpv@pitt.edu.
  • Sutkeviciute I; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, USA.
  • Peña KA; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, USA.
J Biol Chem ; 297(3): 101118, 2021 09.
Article em En | MEDLINE | ID: mdl-34437901
cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein-coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: AMP Cíclico / Proteômica Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: AMP Cíclico / Proteômica Idioma: En Ano de publicação: 2021 Tipo de documento: Article