Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers.
Int J Environ Res Public Health
; 18(16)2021 08 17.
Article
em En
| MEDLINE
| ID: mdl-34444430
ABSTRACT
The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis of neurological emergencies. Recently, some Western studies have shown that the current upper reference limit of CSF-TP is quite low for older patients. However, little is reported about the concentration of CSF-TP in the older Asian population. In this study, we retrospectively analyzed the CSF-TP concentrations in healthy older Japanese volunteers. CSF samples in 69 healthy Japanese volunteers (age range 55-73 years) were collected by lumbar puncture, and the data of CSF were retrospectively analyzed. The mean (standard deviation) CSF-TP was 41.7 (12.3) mg/dL. The older group (≥65 years old) had higher CSF-TP concentration than the younger group (55-64 years old). The 2.5th percentile and 97.5th percentile of CSF-TP were estimated as 22.5 and 73.2 mg/dL, respectively, which were higher than the current reference range in Japan (10-40 mg/dL). Conclusions:
The reference interval of CSF-TP in the older population should be reconsidered for the precise diagnosis of neurological emergencies.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Voluntários
/
Proteínas do Líquido Cefalorraquidiano
Tipo de estudo:
Observational_studies
Limite:
Aged
/
Humans
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article