Transient Depletion of Foxp3<sup>+</sup> Regulatory T Cells Selectively Promotes Aggressive ß Cell Autoimmunity in Genetically Susceptible DEREG Mice.

Watts, Deepika; Janßen, Marthe; Jaykar, Mangesh; Palmucci, Francesco; Weigelt, Marc; Petzold, Cathleen; Hommel, Angela; Sparwasser, Tim; Bonifacio, Ezio; Kretschmer, Karsten

Transient Depletion of Foxp3⁺ Regulatory T Cells Selectively Promotes Aggressive ß Cell Autoimmunity in Genetically Susceptible DEREG Mice.

Watts, Deepika; Janßen, Marthe; Jaykar, Mangesh; Palmucci, Francesco; Weigelt, Marc; Petzold, Cathleen; Hommel, Angela; Sparwasser, Tim; Bonifacio, Ezio; Kretschmer, Karsten.

Afiliação

Watts D; Molecular and Cellular Immunology/Immune Regulation, Center for Regenerative Therapies Dresden (CRTD), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
Janßen M; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.
Jaykar M; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Palmucci F; Molecular and Cellular Immunology/Immune Regulation, Center for Regenerative Therapies Dresden (CRTD), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
Weigelt M; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.
Petzold C; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Hommel A; Molecular and Cellular Immunology/Immune Regulation, Center for Regenerative Therapies Dresden (CRTD), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
Sparwasser T; Molecular and Cellular Immunology/Immune Regulation, Center for Regenerative Therapies Dresden (CRTD), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
Bonifacio E; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.
Kretschmer K; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.

Front Immunol ; 12: 720133, 2021.

Article em En | MEDLINE | ID: mdl-34447385

Assuntos

Autoimunidade; Diabetes Mellitus Tipo 1/etiologia; Diabetes Mellitus Tipo 1/metabolismo; Fatores de Transcrição Forkhead/metabolismo; Células Secretoras de Insulina/imunologia; Células Secretoras de Insulina/metabolismo; Linfócitos T Reguladores/imunologia; Linfócitos T Reguladores/metabolismo; Transferência Adotiva/métodos; Animais; Anticorpos Monoclonais/farmacologia; Complexo CD3/antagonistas & inibidores; Diabetes Mellitus Tipo 1/diagnóstico; Diabetes Mellitus Tipo 1/terapia; Modelos Animais de Doenças; Suscetibilidade a Doenças; Feminino; Imunofenotipagem; Depleção Linfocítica; Masculino; Camundongos; Camundongos Endogâmicos NOD; Camundongos Knockout; Camundongos Transgênicos; Fenótipo

Palavras-chave

Foxp3; Treg cells; cell ablation; immune regulation; type 1 diabetes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoimunidade / Linfócitos T Reguladores / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina / Fatores de Transcrição Forkhead Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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