Antiretroviral therapy outcomes among adolescents and young adults in a Tertiary hospital in Kenya.
Afr Health Sci
; 21(Suppl): 1-7, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-34447417
ABSTRACT
BACKGROUND:
Limited data is available on the treatment outcomes of HIV infected adolescents and young adults (AYA) in sub-Saharan Africa. HIV-infected adolescents and young adults (AYA) are at high risk of developing antiretroviral treatment failure.OBJECTIVE:
To determine the clinical, immunological and virologic outcomes of AYA at a tertiary hospital in Kenya.METHODOLOGY:
A longitudinal study was conducted among AYA age 10-24 years attending Kenyatta National Hospital comprehensive care center. Clinical data was abstracted from electronic medical records for study participants with at least 6 months of follow-up using a structured data abstraction sheet.RESULTS:
A total of 250 AYA age 10 to 24 years were included. The median age was 16 years. The median CD4 cell count was 650.6 cells/mm3 (IQR 350.7-884.0). More than half (60.6%) of AYA had a CD4 cell count higher than 500 cells/mm3. Overall, 76.9% of AYA had achieved viral suppression (viral load <1000 copies/ml). There was a significant increase in virologic failure with higher age and late adolescents and young adults were more likely to have a viral load > 1000 copies/ml p<0.012.CONCLUSION:
The overall virologic suppression in this cohort of AYA was sub-optimal. Both immunological and virologic outcomes were worse among late adolescents (18-19 years) and young adults (20-24 years).Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Fármacos Anti-HIV
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Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
/
Humans
/
Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article