The application of oncolytic viruses in cancer therapy.
Biotechnol Lett
; 43(10): 1945-1954, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34448096
ABSTRACT
Oncolytic therapy is a treatment method used to directly combat tumor cells by modifying the genes of naturally occurring low pathogenic viruses to form "rhizobia" virus. By taking the advantage of abnormal signal pathways in cancer cells, it selectively replicates in tumor cells leading to tumor cell lysis and death. At present, clinical studies widely employ biomolecular technology to transform oncolytic viruses to exert stronger oncolytic effects and reduce their adverse reactions. This review summarizes the current progresses and the molecular mechanism of oncolytic viruses towards tumor treatment and management.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus Oncolíticos
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Terapia Viral Oncolítica
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article