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PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
Kroth, Heiko; Oden, Felix; Molette, Jerome; Schieferstein, Hanno; Gabellieri, Emanuele; Mueller, Andre; Berndt, Mathias; Sreenivasachary, Nampally; Serra, Andreia Monica; Capotosti, Francesca; Schmitt-Willich, Heribert; Hickman, David; Pfeifer, Andrea; Dinkelborg, Ludger; Stephens, Andrew.
Afiliação
  • Kroth H; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Oden F; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Molette J; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Schieferstein H; Formerly Piramal Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Gabellieri E; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Mueller A; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Berndt M; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Sreenivasachary N; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Serra AM; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Capotosti F; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Schmitt-Willich H; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Hickman D; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Pfeifer A; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Dinkelborg L; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Stephens A; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
J Med Chem ; 64(17): 12808-12830, 2021 09 09.
Article em En | MEDLINE | ID: mdl-34455780
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traçadores Radioativos / Proteínas tau / Tauopatias / Tomografia por Emissão de Pósitrons / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traçadores Radioativos / Proteínas tau / Tauopatias / Tomografia por Emissão de Pósitrons / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article