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The effect of fish oil on inflammation markers in adult patients undergoing hemodialysis: A meta-analysis.
Zhou, Jiandong; Tang, Gang; Tang, Shaowen; Yuan, Weijie.
Afiliação
  • Zhou J; Shanghai General Hospital, Nanjing Medical University, Shanghai, China.
  • Tang G; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Tang S; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
  • Yuan W; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Semin Dial ; 35(1): 6-14, 2022 01.
Article em En | MEDLINE | ID: mdl-34459522
OBJECTIVE: This meta-analysis was to assess the effect of fish oil supplementation on inflammation markers in adult patients receiving hemodialysis. METHODS: CENTRAL, EMBASE, MEDLINE databases were searched from inception to 10 April 2020. Two authors independently searched, selected, and screened the literature. The pooled results are represented by WMD or SMD with 95% confidence intervals. Subgroup analysis and meta-regression were used to explore sources of heterogeneity, and sensitivity analysis was used to assess the robustness of the pooled results. Funnel plots were used to assess publication bias. RESULTS: Eleven RCT (randomized control trials) studies were included. The pooled results showed that fish oil supplementation caused a significant reduction of the CRP(C-reactive protein) level (random model: WMD, -3.36, 95%CI: -5.46 to -1.26, P = .002), especially in patients with baseline CRP ≥ 5 mg/L (random model: WMD, -4.43, 95%CI: -6.10 to -2.76, P = .00001, I2  = 41%). Meta-regression analyses showed that CRP baseline level (CRP < 5 mg/L) was the main source of heterogeneity (P = .036). Sensitive analyses revealed that the result was hardly changed. Fish oil supplementation might not reduce the level of IL-6 (random model: WMD, -2.26, 95%CI: -19.61 to 15.09, P = .80) in four studies or the level of TNF-α (random model: SMD, -2.51, 95%CI: -6.08 to 1.06, P = .17) in three studies. CONCLUSIONS: Fish oil supplementation could reduce the level of CRP in hemodialysis patients, especially in patients with CRP ≥ 5 mg/L, but had no effects on IL-6 and TNF-α.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óleos de Peixe / Suplementos Nutricionais / Inflamação Tipo de estudo: Clinical_trials / Prognostic_studies / Systematic_reviews Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óleos de Peixe / Suplementos Nutricionais / Inflamação Tipo de estudo: Clinical_trials / Prognostic_studies / Systematic_reviews Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article