Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca<sup>2+</sup>-calmodulin binding.

Amini, Mahnaz; Chang, Yiming; Wissenbach, Ulrich; Flockerzi, Veit; Schlenstedt, Gabriel; Beck, Andreas

Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca²⁺-calmodulin binding.

Amini, Mahnaz; Chang, Yiming; Wissenbach, Ulrich; Flockerzi, Veit; Schlenstedt, Gabriel; Beck, Andreas.

Afiliação

Amini M; Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS, Universität des Saarlandes, Homburg, Deutschland; Department of Medical Biochemistry and Molecular Biology/PZMS, Medical School, Saarland University, Homburg, Germany.
Chang Y; Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS, Universität des Saarlandes, Homburg, Deutschland; Department of Medical Biochemistry and Molecular Biology/PZMS, Medical School, Saarland University, Homburg, Germany.
Wissenbach U; Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS, Universität des Saarlandes, Homburg, Deutschland.
Flockerzi V; Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS, Universität des Saarlandes, Homburg, Deutschland.
Schlenstedt G; Department of Medical Biochemistry and Molecular Biology/PZMS, Medical School, Saarland University, Homburg, Germany.
Beck A; Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS, Universität des Saarlandes, Homburg, Deutschland. Electronic address: andreas.beck@uks.eu.

J Biol Chem ; 297(4): 101126, 2021 10.

Article em En | MEDLINE | ID: mdl-34461097

Assuntos

Sinalização do Cálcio; Cálcio/metabolismo; Calmodulina/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo; Canais de Cátion TRPC/metabolismo; Vacúolos/metabolismo; Cálcio/química; Calmodulina/antagonistas & inibidores; Calmodulina/química; Calmodulina/genética; Células HEK293; Humanos; Domínios Proteicos; Saccharomyces cerevisiae; Proteínas de Saccharomyces cerevisiae/química; Proteínas de Saccharomyces cerevisiae/genética; Sesterterpenos/farmacologia; Canais de Cátion TRPC/química; Canais de Cátion TRPC/genética; Vacúolos/química; Vacúolos/genética

Palavras-chave

(45)Ca(2+); Ca(2+) imaging; TRPY1; Yvc1; calcium channel; calmodulin; ion channel; patch clamp; vacuole

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacúolos / Calmodulina / Cálcio / Sinalização do Cálcio / Proteínas de Saccharomyces cerevisiae / Canais de Cátion TRPC Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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