Achyrophenols A-F: Polycyclic Polyphenol Lactone Skeletons and a Nor-Ursane-Type Triterpenoid from Achyrocline Satureioides.
J Org Chem
; 86(18): 12813-12820, 2021 09 17.
Article
em En
| MEDLINE
| ID: mdl-34464127
ABSTRACT
Two novel derivatives of 2-methyl-1-(2,3,4,6-tetrahydroxyphenyl)propan-1-one and (S)-2-methyl-1-(2,3,4,6-tetrahydroxyphenyl)butan-1-one (1 and 2), four novel six-membered lactone phenols (3-6), and a nor-ursane type triterpenoid (7) named Achroacid, were isolated from the aerial part of Achyrocline satureioides. The absolute configurations of 1-7 are presented by spectroscopic data and X-ray crystallographic analysis. A DP4plus evaluation was applied to determine the final stereochemistry for 1 and 2. The biosynthesis pathway of 1 and 2 was proposed. 1 has potential on anti-Gram-negative bacteria. Both 1 and 2 exhibited a significant impact on anti-H1299 cells. Compounds 3-7 showed moderate cancer cell lethality and significant anti-inflammatory activities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Achyrocline
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article