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Three regulatory compliant test systems show no signs of MDMA-related genotoxicity.
Cohen, Isaac Victor; Barber, Laken; Dubnicka, Tyson Paul; Hurtado, Sara Beth; Tincher, Sarah Ann; Stankowski, Leon Frank; Yazar-Klosinski, Berra.
Afiliação
  • Cohen IV; Clinical Pharmacology and Therapeutics (CPT) Postdoctoral Training Program, University of California San Francisco, San Francisco, CA, USA.
  • Barber L; Division of Biochemistry, Hawai'i Pacific University, Honolulu, Hawaii.
  • Dubnicka TP; Safety Department, MAPS Public Benefit Corporation, San Jose, CA, USA.
  • Hurtado SB; Charles River Laboratories, Mattawan, MI, USA.
  • Tincher SA; Charles River Laboratories, Skokie, IL, USA.
  • Stankowski LF; Charles River Laboratories, Skokie, IL, USA.
  • Yazar-Klosinski B; Charles River Laboratories, Skokie, IL, USA.
J Psychopharmacol ; 35(11): 1431-1434, 2021 11.
Article em En | MEDLINE | ID: mdl-34465250
3,4 Methylenedioxymethamphetamine (MDMA)-assisted therapy has been recently found to be highly effective for treatment of posttraumatic stress disorder (PTSD). Previous studies have been inconclusive in elucidating potential MDMA genotoxicity. We performed three regulatory compliant studies to investigate the potential of genotoxic effects of MDMA treatment in humans: (1) an in vitro bacterial reverse mutation (Ames) assay, (2) an in vitro chromosome aberration test in Chinese hamster ovary cells, and (3) an in vivo micronucleus study in male Sprague Dawley rats. MDMA was found to not have genotoxic effects in any of the assays at or above clinically relevant concentrations.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Salmonella typhimurium / Transtornos de Estresse Pós-Traumáticos / Aberrações Cromossômicas / Células CHO / Neurotransmissores / N-Metil-3,4-Metilenodioxianfetamina / Escherichia coli Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Salmonella typhimurium / Transtornos de Estresse Pós-Traumáticos / Aberrações Cromossômicas / Células CHO / Neurotransmissores / N-Metil-3,4-Metilenodioxianfetamina / Escherichia coli Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article