Evolution of Coronavirus Disease 2019 (COVID-19) Symptoms During the First 12 Months After Illness Onset.
Clin Infect Dis
; 75(1): e482-e490, 2022 08 24.
Article
em En
| MEDLINE
| ID: mdl-34473245
ABSTRACT
BACKGROUND:
Few robust longitudinal data on long-term coronavirus disease 2019 (COVID-19) symptoms are available. We evaluated symptom onset, severity and recovery across the full spectrum of disease severity, up to one year after illness onset.METHODS:
The RECoVERED Study is a prospective cohort study based in Amsterdam, the Netherlands. Participants agedâ ≥18 years were enrolled following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis via the local public health service and from hospitals. Standardized symptom questionnaires were completed at enrollment, 1 week and month later, and monthly thereafter. Clinical severity was defined according to World Health Organization (WHO) criteria. Kaplan-Meier methods were used to compare time from illness onset to symptom recovery, by clinical severity. We examined determinants of time to recovery using multivariable Cox proportional hazards models.RESULTS:
Between 11 May 2020 and 1 May 2021, 342 COVID-19 patients (192 [56%] male) were enrolled, of whom 99/342 (29%) had mild, 145/342 (42%) moderate, 56/342 (16%) severe, and 42/342 (12%) critical disease. The proportion of participants who reported at least 1 persistent symptom at 12 weeks after illness onset was greater in those with severe/critical disease (86.7% [95% confidence interval {CI}â =â 76.5-92.7%]) compared to those with mild or moderate disease (30.7% [95% CIâ =â 21.1-40.9%] and 63.8% [95% CIâ =â 54.8-71.5%], respectively). At 12 months after illness onset, two-fifths of participants (40.7% [95% CIâ =â 34.2-7.1]) continued to reportâ ≥1 symptom. Recovery was slower in female compared to male participants (adjusted hazard ratio [aHR] 0.65 [95% CIâ =â .47-.92]) and those with a body mass index [BMI] â ≥30kg/m2 compared to BMIâ <25kg/m2 (hazard ratio [HR] 0.62 [95% CIâ =â .39-.97]).CONCLUSIONS:
COVID-19 symptoms persisted for one year after illness onset, even in some individuals with mild disease. Female sex and obesity were the most important determinants of speed of recovery from symptoms.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article