Acute liver failure due to herpes simplex virus: diagnostic clues and potential role of plasmapheresis: A case report.
Medicine (Baltimore)
; 100(35): e27139, 2021 Sep 03.
Article
em En
| MEDLINE
| ID: mdl-34477166
ABSTRACT
INTRODUCTION:
Acute liver failure (ALF) is a life-threatening condition that remains challenging for physicians despite several advances in supportive care. Etiologies vary worldwide, with herpes simplex virus (HSV) hepatitis representing less than 1% of cases. Despite its low incidence, ALF is a lethal cause of acute necrotizing hepatitis and has a high mortality. Early antiviral treatment is beneficial for survival and decreased liver transplantation necessity. However, plasmapheresis, despite its theoretical potential benefit, is scarcely reported. PATIENT CONCERNS A 25-year-old woman with no known disease presented with painful pharynx ulcers, increased transaminases and impaired liver function. DIAGNOSIS ALF due to a disseminated HSV-2 primary infection was diagnosed with a positive polymerase chain reaction for HSV-2 in the biopsied liver tissue and blood.INTERVENTIONS:
Empiric antiviral treatment was initiated. After clinical deterioration, plasmapheresis was also initiated.OUTCOMES:
After 6 cycles of plasmapheresis and supportive care, the patient's condition improved without undergoing liver transplantation.CONCLUSIONS:
ALF is a life-threatening condition, and HSV as an etiology must be suspected based on background, clinical manifestation, and laboratory information. The potential role of plasmapheresis in HSV hepatitis should be considered.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Aciclovir
/
Plasmaferese
/
Falência Hepática Aguda
/
Herpes Simples
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article