Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

Zhao, Yang; Cheng, Rui; Zhao, Yue; Ge, Wenhao; Yang, Yunxia; Ding, Zhao; Xu, Xi; Wang, Zhongqiu; Wu, Zhenguo; Zhang, Jianfa

Zhao, Yang; Cheng, Rui; Zhao, Yue; Ge, Wenhao; Yang, Yunxia; Ding, Zhao; Xu, Xi; Wang, Zhongqiu; Wu, Zhenguo; Zhang, Jianfa.

Afiliação

Zhao Y; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China.
Cheng R; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China.
Zhao Y; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore.
Ge W; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China.
Yang Y; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China.
Ding Z; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China.
Xu X; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China.
Wang Z; Affiliated Hospital of Nanjing, University of Chinese Medicine, Nanjing, China.
Wu Z; Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, China.
Zhang J; Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China. Electronic address: jfzhang@mail.njust.edu.cn.

J Biol Chem ; 297(4): 101166, 2021 10.

Article em En | MEDLINE | ID: mdl-34487763

Assuntos

Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Hibernação; Ácido Úrico/metabolismo; Trifosfato de Adenosina/genética; Trifosfato de Adenosina/metabolismo; Trifosfato de Adenosina/farmacologia; Animais; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/patologia; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/patologia; Cães; Hiperuricemia/genética; Hiperuricemia/metabolismo; Hiperuricemia/patologia; Masculino; Camundongos; Camundongos Knockout; Ratos; Trocadores de Sódio-Hidrogênio/genética; Trocadores de Sódio-Hidrogênio/metabolismo

Palavras-chave

ATP; hibernation; pH regulation; sodiumproton exchange; suspended animation; type 2 diabetes; uric acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Úrico / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Hibernação Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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