Antitumor immunity in strain 2 guinea pigs immunized with potassium chloride extracts of L2C tumor cells.
J Natl Cancer Inst
; 60(4): 899-903, 1978 Apr.
Article
em En
| MEDLINE
| ID: mdl-344900
ABSTRACT
Extracts of L2C tumor cells stimulated in vitro production of macrophage migration inhibitory factor (MIF) in peritoneal exudate cells from guinea pigs immunized with L2C tumor cells. Guinea pigs immunized with extracts of L2C tumor cells that were active in vitro (in the MIF assay) were completely resistant to challenge with viable tumor cells given 2 weeks later. Furthermore, guinea pigs immunized with extracts of L2C tumor cells within 1 hour after challenge with viable L2C tumor cells survived substantially longer than did nonimmunized controls. The immunoprotective and immunotherapeutic effects seen in guinea pigs given injections of viable L2C tumor cells were obtained with extracts of L2C tumor cells but not with extracts of another guinea pig tumor (line 10 hepatoma) or with extracts of normal guinea pig lymphoid cells.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Experimental
/
Imunidade
/
Antígenos de Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article