Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway.

Olzhausen, Judith; Grigat, Mathias; Seifert, Larissa; Ulbricht, Tom; Schüller, Hans-Joachim

Olzhausen, Judith; Grigat, Mathias; Seifert, Larissa; Ulbricht, Tom; Schüller, Hans-Joachim.

Afiliação

Olzhausen J; Center for Functional Genomics of Microbes, Abteilung Molekulare Genetik und Infektionsbiologie, Universität Greifswald, Felix-Hausdorff-Strasse 8, 17487, Greifswald, Germany.
Grigat M; Cendres+Métaux SA, CH-2501, Biel/Bienne, Switzerland.
Seifert L; Center for Functional Genomics of Microbes, Abteilung Molekulare Genetik und Infektionsbiologie, Universität Greifswald, Felix-Hausdorff-Strasse 8, 17487, Greifswald, Germany.
Ulbricht T; Center for Functional Genomics of Microbes, Abteilung Molekulare Genetik und Infektionsbiologie, Universität Greifswald, Felix-Hausdorff-Strasse 8, 17487, Greifswald, Germany.
Schüller HJ; Universitätsklinikum Hamburg-Eppendorf, Medizinische Klinik, Nephrologie, Hamburg, Germany.

Appl Microbiol Biotechnol ; 105(19): 7321-7337, 2021 Oct.

Article em En | MEDLINE | ID: mdl-34491400

Assuntos

Acetilcoenzima A/biossíntese; Fosfotransferases (Aceptor do Grupo Álcool)/genética; Saccharomyces cerevisiae; Vias Biossintéticas/genética; Microbiologia Industrial; Microrganismos Geneticamente Modificados; Saccharomyces cerevisiae/genética

Palavras-chave

Acetyl-CoA; Biosynthesis of coenzyme A; CAB genes; Feedback inhibition; Pantothenate kinase; Saccharomyces cerevisiae; Yeast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcoenzima A / Saccharomyces cerevisiae / Fosfotransferases (Aceptor do Grupo Álcool) Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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