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In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Shan, Lu; Dyk, Nydia Van; Haskins, Nantaporn; Cook, Kimberly M; Rosenthal, Kim L; Mazor, Ronit; Dragulin-Otto, Sonia; Jiang, Yu; Wu, Herren; Dall'Acqua, William F; Borrok, Martin J; Damschroder, Melissa M; Oganesyan, Vaheh.
Afiliação
  • Shan L; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA. shan@dnli.com.
  • Dyk NV; Denali Therapeutics, South San Francisco, CA, USA. shan@dnli.com.
  • Haskins N; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Cook KM; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Rosenthal KL; Early Oncology, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Mazor R; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Dragulin-Otto S; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Jiang Y; Division of Cellular and Gene Therapies, FDA Center for Biologics Evaluation and Research, Silver Spring, MD, USA.
  • Wu H; Dosage Form Design and Development, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Dall'Acqua WF; Clinical Pharmacology and Safety Science, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Borrok MJ; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Damschroder MM; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Oganesyan V; Janssen BioTherapeutics, Janssen Research and Development, Spring House, PA, USA.
Commun Biol ; 4(1): 1048, 2021 09 08.
Article em En | MEDLINE | ID: mdl-34497355
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos Fc das Imunoglobulinas / Receptores Fc / Antígenos de Histocompatibilidade Classe I Tipo de estudo: Guideline Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos Fc das Imunoglobulinas / Receptores Fc / Antígenos de Histocompatibilidade Classe I Tipo de estudo: Guideline Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article