Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?
Biomark Med
; 15(15): 1377-1388, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34514843
ABSTRACT
Aim:
The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Materials &methods:
Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped patients by a broad category of diseases. Results &conclusion:
Compared with healthy controls, in patients with Alzheimer's disease, hsa-miR-767-5p was overexpressed (p < 0.001) and in patients with Huntington's disease, hsa-miR-361-3p was underexpressed (p < 10-4). We also define a subset of extracellular miRNA as candidate biomarkers that are robustly detected across patients, studies and diseases; thereby, warranting further study.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Doenças Neurodegenerativas
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Perfilação da Expressão Gênica
/
MicroRNAs
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Redes Reguladoras de Genes
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article