Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development.
EMBO Rep
; 22(11): e53048, 2021 11 04.
Article
em En
| MEDLINE
| ID: mdl-34515391
ABSTRACT
During implantation, the murine embryo transitions from a "quiet" into an active metabolic/proliferative state, which kick-starts the growth and morphogenesis of the post-implantation conceptus. Such transition is also required for embryonic stem cells to be established from mouse blastocysts, but the factors regulating this process are poorly understood. Here, we show that Ronin plays a critical role in the process by enabling active energy production, and the loss of Ronin results in the establishment of a reversible quiescent state in which naïve pluripotency is promoted. In addition, Ronin fine-tunes the expression of genes that encode ribosomal proteins and is required for proper tissue-scale organisation of the pluripotent lineage during the transition from blastocyst to egg cylinder stage. Thus, Ronin function is essential for governing the metabolic capacity so that it can support the pluripotent lineage's high-energy demands for cell proliferation and morphogenesis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desenvolvimento Embrionário
/
Células-Tronco Embrionárias
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article