Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli.
Commun Biol
; 4(1): 1068, 2021 09 14.
Article
em En
| MEDLINE
| ID: mdl-34521984
ABSTRACT
Recent evidence suggests that metabolic shutdown alone does not fully explain how bacteria exhibit phenotypic antibiotic tolerance. In an attempt to investigate the range of starvation-induced physiological responses underlying tolerance development, we found that active maintenance of the transmembrane proton motive force (PMF) is essential for prolonged expression of antibiotic tolerance in bacteria. Eradication of tolerant sub-population could be achieved by disruption of PMF using the ionophore CCCP, or through suppression of PMF maintenance mechanisms by simultaneous inhibition of the phage shock protein (Psp) response and electron transport chain (ETC) complex activities. We consider disruption of bacterial PMF a feasible strategy for treatment of chronic and recurrent bacterial infections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Força Próton-Motriz
/
Farmacorresistência Bacteriana
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Escherichia coli
/
Antibacterianos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article