Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons.
J Inflamm Res
; 14: 4503-4507, 2021.
Article
em En
| MEDLINE
| ID: mdl-34522118
ABSTRACT
Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.
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MEDLINE
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En
Ano de publicação:
2021
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Article