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Fluorescent light energy modulates healing in skin grafted mouse model.
Ding, Jie; Mellergaard, Maiken; Zhu, Zhensen; Kwan, Peter; Edge, Deirdre; Ma, Zengshuan; Hebert, Lise; Alrobaiea, Saad; Iwasaki, Takashi; Nielsen, Michael Canova Engelbrecht; Tredget, Edward E.
Afiliação
  • Ding J; Wound Healing Research Group, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, 161 HMRC, Edmonton, Canada.
  • Mellergaard M; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Zhu Z; Department of Research and Development, Klox Technologies Europe Ltd, Dublin, Ireland.
  • Kwan P; Wound Healing Research Group, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, 161 HMRC, Edmonton, Canada.
  • Edge D; Wound Healing Research Group, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, 161 HMRC, Edmonton, Canada.
  • Ma Z; Department of Research and Development, Klox Technologies Europe Ltd, Dublin, Ireland.
  • Hebert L; Wound Healing Research Group, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, 161 HMRC, Edmonton, Canada.
  • Alrobaiea S; Department of Research and Development, Klox Technologies Inc., Laval, Canada.
  • Iwasaki T; Wound Healing Research Group, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, 161 HMRC, Edmonton, Canada.
  • Nielsen MCE; Wound Healing Research Group, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, 161 HMRC, Edmonton, Canada.
  • Tredget EE; Department of Research and Development, Klox R&D Center, Guangdong Klox Biomedical Group Co., Ltd, Room 603, 6/F, Building 8, No. 6, Nanjiang Second Road, Zhujiang Street, Nansha District, Guangzhou, China.
Open Med (Wars) ; 16(1): 1240-1255, 2021.
Article em En | MEDLINE | ID: mdl-34522783
Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing. This study investigated the effect of fluorescent light energy (FLE) therapy, a novel type of PBM, on healing after skin grafting in a dermal fibrotic mouse model. Split-thickness human skin grafts were transplanted onto full-thickness excisional wounds on nude mice. Treated wounds were monitored, and excised xenografts were examined to assess healing and pathophysiological processes essential for developing chronic wounds or scarring. Results demonstrated that FLE treatment initially accelerated re-epithelialization and rete ridge formation, while later reduced neovascularization, collagen deposition, myofibroblast and mast cell accumulation, and connective tissue growth factor expression. While there was no visible difference in gross morphology, we found that FLE treatment promoted a balanced collagen remodeling. Collectively, these findings suggest that FLE has a conceivable effect at balancing healing after skin grafting, which reduces the risk of infections, chronic wound development, and fibrotic scarring.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article