Regulation of hemidesmosome dynamics and cell signaling by integrin α6ß4.
J Cell Sci
; 134(18)2021 09 15.
Article
em En
| MEDLINE
| ID: mdl-34523678
ABSTRACT
Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes to the underlying basement membrane. Integrin α6ß4 is a receptor for laminins and plays a vital role in mediating cell adhesion by initiating the assembly of HDs. In addition, α6ß4 has been implicated in signal transduction events that regulate diverse cellular processes, including proliferation and survival. In this Review, we detail the role of α6ß4 in HD assembly and beyond, and we discuss the molecular mechanisms that regulate its function.
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Base de dados:
MEDLINE
Assunto principal:
Hemidesmossomos
/
Integrina alfa6beta4
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article