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Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.
Xi, Weixian; Hegde, Vishal; Zoller, Stephen D; Park, Howard Y; Hart, Christopher M; Kondo, Takeru; Hamad, Christopher D; Hu, Yan; Loftin, Amanda H; Johansen, Daniel O; Burke, Zachary; Clarkson, Samuel; Ishmael, Chad; Hori, Kellyn; Mamouei, Zeinab; Okawa, Hiroko; Nishimura, Ichiro; Bernthal, Nicholas M; Segura, Tatiana.
Afiliação
  • Xi W; Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, United States.
  • Hegde V; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Zoller SD; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Park HY; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Hart CM; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Kondo T; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Hamad CD; Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of Dentistry, Los Angeles, CA, United States.
  • Hu Y; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Loftin AH; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Johansen DO; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Burke Z; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Clarkson S; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Ishmael C; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Hori K; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Mamouei Z; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Okawa H; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
  • Nishimura I; Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of Dentistry, Los Angeles, CA, United States.
  • Bernthal NM; Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of Dentistry, Los Angeles, CA, United States.
  • Segura T; Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States. NBernthal@mednet.ucla.edu.
Nat Commun ; 12(1): 5473, 2021 09 16.
Article em En | MEDLINE | ID: mdl-34531396
ABSTRACT
Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Infecções Relacionadas à Prótese / Sistemas Automatizados de Assistência Junto ao Leito / Materiais Revestidos Biocompatíveis / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Infecções Relacionadas à Prótese / Sistemas Automatizados de Assistência Junto ao Leito / Materiais Revestidos Biocompatíveis / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article