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Low-Iodine Diet of 4 Days Is Sufficient Preparation for 131I Therapy in Differentiated Thyroid Cancer Patients.
Dekker, Bernadette L; Links, Mirthe H; Muller Kobold, Anneke C; Swart-Busscher, Linda G; Kars, Marleen; Bons, Judith A P; Brouwers, Adrienne H; Links, Thera P; van der Horst-Schrivers, Anouk N A.
Afiliação
  • Dekker BL; University of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.
  • Links MH; University of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.
  • Muller Kobold AC; University of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, 9700 RB Groningen, the Netherlands.
  • Swart-Busscher LG; University of Groningen, University Medical Center Groningen, Department of Paramedical Sciences, 9700 RB Groningen, the Netherlands.
  • Kars M; Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center, 6202 AZ, Maastricht, the Netherlands.
  • Bons JAP; Central Diagnostic Laboratory, Maastricht University Medical Center, 6202 AZ, Maastricht, the Netherlands.
  • Brouwers AH; University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, 9700 RB Groningen, the Netherlands.
  • Links TP; University of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.
  • van der Horst-Schrivers ANA; University of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.
J Clin Endocrinol Metab ; 107(2): e604-e611, 2022 01 18.
Article em En | MEDLINE | ID: mdl-34534327
CONTEXT: No consensus exists about the optimal duration of the low-iodine diet (LID) in the preparation of 131I therapy in differentiated thyroid cancer (DTC) patients. OBJECTIVE: This work aimed to investigate if a LID of 4 days is enough to achieve adequate iodine depletion in preparation for 131I therapy. In addition, the nutritional status of the LID was evaluated. METHODS: In this prospective study, 65 DTC patients treated at 2 university medical centers were included between 2018 and 2021. The patients collected 24-hour urine on days 4 and 7 of the LID and kept a food diary before and during the LID. The primary outcome was the difference between the 24-hour urinary iodine excretion (UIE) on both days. RESULTS: The median 24-hour UIE on days 4 and 7 of the LID were not significantly different (36.1 mcg [interquartile range, 25.4-51.2 mcg] and 36.5 mcg [interquartile range, 23.9-47.7 mcg], respectively, P = .43). On day 4 of the LID, 72.1% of the DTC patients were adequately prepared (24-hour UIE < 50 mcg), and 82.0% of the DTC patients on day 7 (P = .18). Compared to the self-reported regular diet, DTC patients showed a significantly (P < .01) lower percentage of nutrient intake (calories, protein, calcium, iodine, and water) during the LID. CONCLUSION: The 24-hour UIE on day 4 of the LID did not differ from day 7, and therefore shortening the LID from 7 to 4 days seems justified to prepare DTC patients for 131I therapy in areas with sufficient iodine intake and may be beneficial to maintain a sufficient nutritional intake during DTC treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligoelementos / Neoplasias da Glândula Tireoide / Dieta / Iodo / Radioisótopos do Iodo Tipo de estudo: Clinical_trials / Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligoelementos / Neoplasias da Glândula Tireoide / Dieta / Iodo / Radioisótopos do Iodo Tipo de estudo: Clinical_trials / Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article