Identification of variant APL translocations PRKAR1A-RAR&#945; and ZBTB16-RAR&#945; (PLZF-RAR&#945;) through the MI-ONCOSEQ platform.

King, Darren; Foucar, Charles E; Ma, Vincent; Benitez, Lydia; Perissinotti, Anthony J; Marini, Bernard L; Robinson, Dan; Bhave, Rupali Roy; Bixby, Dale

Identification of variant APL translocations PRKAR1A-RARα and ZBTB16-RARα (PLZF-RARα) through the MI-ONCOSEQ platform.

King, Darren; Foucar, Charles E; Ma, Vincent; Benitez, Lydia; Perissinotti, Anthony J; Marini, Bernard L; Robinson, Dan; Bhave, Rupali Roy; Bixby, Dale.

Afiliação

King D; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Foucar CE; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Ma V; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Benitez L; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
Perissinotti AJ; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
Marini BL; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
Robinson D; Michigan Center for Translational Pathology, Michigan Medicine, Ann Arbor, Michigan, USA.
Bhave RR; Division of Hematology and Medical Oncology, Wake Forrest University, Winston-Salem, North Carolina, USA.
Bixby D; Division of Hematology and Medical Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA. Electronic address: dbixby@umich.edu.

Cancer Genet ; 258-259: 57-60, 2021 11.

Article em En | MEDLINE | ID: mdl-34534739

Assuntos

Subunidade RIalfa da Proteína Quinase Dependente de AMP Cíclico/genética; Rearranjo Gênico; Leucemia Promielocítica Aguda/genética; Leucemia Promielocítica Aguda/patologia; Proteínas de Fusão Oncogênica/genética; Receptor alfa de Ácido Retinoico/genética; Translocação Genética; Adulto; Idoso; Feminino; Humanos; Prognóstico; Adulto Jovem

Palavras-chave

Acute Promyelocytic Leukemia; PRKAR1A-RARα; Swhole exome and transcriptome profiling; Variant translocation; ZBTB16-RARα

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Rearranjo Gênico / Leucemia Promielocítica Aguda / Proteínas de Fusão Oncogênica / Subunidade RIalfa da Proteína Quinase Dependente de AMP Cíclico / Receptor alfa de Ácido Retinoico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Adult / Aged / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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