miR-495 Regulates Cellular Reactive Oxygen Species Levels by Targeting sod2 To Inhibit Intracellular Survival of Mycobacterium tuberculosis in Macrophages.
Infect Immun
; 89(12): e0031521, 2021 11 16.
Article
em En
| MEDLINE
| ID: mdl-34543119
ABSTRACT
Mycobacterium tuberculosis is a chronic infectious disease pathogen. To date, tuberculosis is a major infectious disease that endangers human health. To better prevent and treat tuberculosis, it is important to study the pathogenesis of M. tuberculosis. Based on early-stage laboratory research results, in this study, we verified the upregulation of sod2 in Bacillus Calmette-Guérin (BCG) and H37Rv infection. By detecting BCG/H37Rv intracellular survival in sod2-silenced and sod2-overexpressing macrophages, sod2 was found to promote the intracellular survival of BCG/H37Rv. miR-495 then was determined to be downregulated by BCG/H37Rv. BCG/H37Rv can upregulate sod2 expression by miR-495 to promote the intracellular survival of BCG/H37Rv through a decline in ROS levels. This study provides a theoretical basis for developing new drug targets and treating tuberculosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
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Tuberculose
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Espécies Reativas de Oxigênio
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MicroRNAs
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Macrófagos
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Mycobacterium tuberculosis
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article