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Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes.
Li, Ao; Li, Lingxuan; Liu, Xing; Chen, Dongxia; Fan, Yifan; Lin, Hongyu; Gao, Jinhao.
Afiliação
  • Li A; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
  • Li L; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
  • Liu X; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
  • Chen D; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
  • Fan Y; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
  • Lin H; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
  • Gao J; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn.
Chem Commun (Camb) ; 57(75): 9622-9625, 2021 Sep 21.
Article em En | MEDLINE | ID: mdl-34546273
ABSTRACT
Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Peroxinitroso / Doença Hepática Induzida por Substâncias e Drogas / Imagem por Ressonância Magnética de Flúor-19 Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Peroxinitroso / Doença Hepática Induzida por Substâncias e Drogas / Imagem por Ressonância Magnética de Flúor-19 Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article