Predictive models for response to non-invasive brain stimulation in stroke: A critical review of opportunities and pitfalls.
Brain Stimul
; 14(6): 1456-1466, 2021.
Article
em En
| MEDLINE
| ID: mdl-34560317
ABSTRACT
BACKGROUND:
Noninvasive brain stimulation has been successfully applied to improve stroke-related impairments in different behavioral domains. Yet, clinical translation is limited by heterogenous outcomes within and across studies. It has been proposed to develop and apply noninvasive brain stimulation in a patient-tailored, precision medicine-guided fashion to maximize response rates and effect magnitude. An important prerequisite for this task is the ability to accurately predict the expected response of the individual patient.OBJECTIVE:
This review aims to discuss current approaches studying noninvasive brain stimulation in stroke and challenges associated with the development of predictive models of responsiveness to noninvasive brain stimulation.METHODS:
Narrative review.RESULTS:
Currently, the field largely relies on in-sample associational studies to assess the impact of different influencing factors. However, the associational approach is not valid for making claims of prediction, which generalize out-of-sample. We will discuss crucial requirements for valid predictive modeling in particular the presence of sufficiently large sample sizes.CONCLUSION:
Modern predictive models are powerful tools that must be wielded with great care. Open science, including data sharing across research units to obtain sufficiently large and unbiased samples, could provide a solid framework for addressing the task of building robust predictive models for noninvasive brain stimulation responsiveness.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Estimulação Transcraniana por Corrente Contínua
/
Reabilitação do Acidente Vascular Cerebral
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article