Histone Deacetylases in the Control of Epidermal Homeostasis: From Chromatin Biology toward Therapy.
J Invest Dermatol
; 142(1): 12-14, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34565558
ABSTRACT
Histone deacetylases (HDACs) induce gene repression and modify the activity of nonhistone proteins. In a new article in the Journal of Investigative Dermatology, Zhu et al. (2021) demonstrate essential roles for HDAC1/2 in maintaining keratinocyte proliferation and survival in adult epidermis and basal cell carcinoma, thus providing a rationale for using HDAC inhibitors for the treatment of hyperproliferative and neoplastic skin disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Histona Desacetilases
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article